منابع مشابه
Limited TCF7L2 Expression in MS Lesions
Multiple sclerosis is the most frequent demyelinating disease in the human CNS characterized by inflammation, demyelination, relative axonal loss and gliosis. Remyelination occurs, but is frequently absent or restricted to a small remyelinated rim at the lesion border. Impaired differentiation of oligodendroglial precursor cells is one factor contributing to limited remyelination, especially in...
متن کاملCortical Lesions in MS: Assessment at 7T
Introduction Multiple sclerosis is generally thought of as a white matter (WM) disease [1], yet there is limited correlation between white matter lesion (WML) load and neurological deficits found clinically [2]. Cortical damage was identified early [3,4] and has recently been correlated with the neurological episodes of MS patients [5]. Pathologically, cortical lesions (CLs) are classified into...
متن کاملReduction in Tcf7l2 Expression Decreases Diabetic Susceptibility in Mice
OBJECTIVE The WNT signaling pathway effector gene TCF7L2 has been associated with an increased risk of type 2 diabetes. However, it remains unclear how this gene affects diabetic pathogenesis. The goal of this study was to investigate the effects of Tcf7l2 haploinsufficiency on metabolic phenotypes in mice. EXPERIMENTAL DESIGN Tcf7l2 knockout (Tcf7l⁻/⁻) mice were generated. Because of the ear...
متن کاملExpression of cyclooxygenase-2 in melanocytic skin lesions by immunohistochemistry
Introduction: cyclooxygenase-2 (COX-2) is involved in pathogenesis of various tumors and possibly malignant skin tumors including malignant melanoma; however, there is not enough information about COX-2 expression in benign melanocytic lesions. In the present study we compared the expression levels of COX-2 in malignant melanoma and benign melanocytic lesions. Method: In this analytical study, ...
متن کاملModulation of Tcf7l2 Expression Alters Behavior in Mice
The comorbidity of type 2 diabetes (T2D) with several psychiatric diseases is well established. While environmental factors may partially account for these co-occurrences, common genetic susceptibilities could also be implicated in the confluence of these diseases. In support of shared genetic burdens, TCF7L2, the strongest genetic determinant for T2D risk in the human population, has been rece...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0072822